MAGnetic Smart Processing
Streamlining the biologics manufacturing process with next-generation magnetic separation
MAGic BioProcessing’s proprietary technology platform employs advanced magnetic separation to deliver a one-step solution for clarification, product capture, and isolation of a broad range of biologics – including monoclonal antibodies, viral vectors, nucleic acids, and cell therapy products. By streamlining process workflows into a single, efficient step, this platform significantly boosts yield, throughput, and cost-efficiency, offering an innovative and scalable approach to next-generation biomanufacturing.
Super-paramagnetic beads
Fast, efficient & gentle separation.
Fully automated systems
Compatible with existing liquid handling systems
1-step clarification & capture
Recovery of biologics directly from crude cell broth
The world’s first scalable solution
From research and pilot-scale to full production.
Streamlining bioprocessing with magnetic beads and automated systems
The integrated approach enables one-step clarification and product capture to reduce the number of steps, simplifying the process. By streamlining downstream operations – replacing centrifugation, depth filtration, and affinity column-chromatography – the platform improves yields, increases throughput, and reduces overall costs.
MAGic™Beads
MAGic™Accio Systems
Did you know?
Applications
Monoclonal antibodies
Monoclonal antibody manufacturing faces many challenges, especially during clarification. High cell densities often lead to insufficient removal during centrifugation, clog filters and/or add steps that reduces yields and increase costs.
Magnetic separation solves these problems by combining clarification and product capture in one streamlined step, replacing centrifugation, filtration, and affinity column-chromatography while boosting yields, throughput, and cost efficiency.
Cell Therapy
Cell therapies, especially allogeneic hiPSC-based therapies, show promise for severe diseases due to self-renewal, differentiation, and ethical advantages. However, their complex manufacturing process present significant barriers that restrict patient access, including high costs and scale-up challenges as well as ensuring patient safety by removal of undifferentiated cells.
Magnetic separation streamlines cell isolation, improving efficiency and scalability.
SPRI-Based Cleanup & Library Prep
High-quality sequencing starts with high-quality DNA. Inconsistent SPRI bead cleanup, slow magnetic separation, and bead sticking create variability, sample loss, and bottlenecks that compromise library preparation. MAGic™SPRI HMW combines superior magnetisation with precise solid-phase reversible immobilisation (SPRI) technology to deliver fast, consistent DNA cleanup and fragment size selection from 100 bp to 5 kb in a single, automation-ready bead solution.
Bridging the gap between upstream processing and downstream processing by replacing legacy methods of clarification
Upstream bioprocessing advancements – like high-density cultures, automation, and single-use technologies – have boosted yield and throughput. However, this intensified productivity does not always translate downstream. Complex feed streams can cause filter clogging, operational stoppages, and maintenance issues. As a consequence, downstream processes have had to adapt, often becoming more complicated and costly.
The root of the problem are the outdated clarification methods – centrifugation and depth filtration – positioned between upstream and downstream operations. These legacy technologies were never fundamentally re-imagined. Instead, they were incrementally improved, despite their drawbacks. Centrifugation is expensive, prone to contamination risks, and can damage delicate biomolecules such as cells. Depth filtration suffers from limited capacity, scalability challenges, and the risk of filter clogging.
Rather than creating truly innovative crossover solutions, many developers have had to rely on ad hoc workarounds downstream. By replacing centrifugation and depth filtration with a disruptive approach – the world’s first scalable magnetic separation solution – we bridge the gap at the clarification step itself to make bioprocessing more unified and efficient.
Download our e-book “Mind the gap between upstream and downstream bioprocessing”