Knowledge Center
Applications
Monoclonal antibodies
Monoclonal antibody manufacturing faces many challenges, especially during clarification. High cell densities often lead to insufficient removal during centrifugation, clog filters and/or add steps that reduces yields and increase costs. Magnetic separation solves these problems by combining clarification and product capture in one streamlined step, replacing centrifugation, filtration, and affinity column-chromatography while boosting yields, throughput, and cost efficiency.
Learn how MAGic BeadsTM for antibody purification can be used for 1-step cell clarification and capture of mAbs directly from crude cell broth – to replace centrifugation and depth filtration with a gentler and more efficient technology for improved yields and productivity.
Cell Therapy
Cell therapies, especially allogeneic hiPSC-based therapies, show promise for severe diseases due to self-renewal, differentiation, and ethical advantages. However, their complex manufacturing process present significant barriers that restrict patient access, including high costs and scale-up challenges as well as ensuring patient safety by removal of undifferentiated cells. Magnetic separation streamlines cell isolation, improving efficiency and scalability.
Learn how MAGic BeadsTM for cell therapy can be used for gentle and efficient isolation and purification of stem cells, viral vectors and cell therapy products for improved yields.
Publications
Side-by-Side Economic Process Model for the Comparison and Evaluation of Magnetic Bead-Based Processes and Legacy Process for the Manufacturing of Monoclonal Antibodies
Brechmann NA, Stamatis C, Farid SS, Chotteau V, Eriksson K
Processes. 2024;12(11):2563
Detection of synthetic analogues of insulin-like growth factor 1 in different biological fluids by liquid chromatography quadrupole time-of-flight mass spectrometry: comparison of different immunoaffinity protocols
Monica Mazzarino, Isabella Melis, Edoardo Quaresima and Francesco Botrè
Springer Nature, Volume 415, pages 6117–6131 (2023)
Accurate determination of the milk protein allergen β-lactoglobulin by on-line aptamer affinity solid-phase extraction capillary electrophoresis-mass spectrometry
María Vergara-Barberán, Ernesto Francisco Simó-Alfonso, José Manuel Herrero-Martínez, Fernando Benavente
Talanta, Volume 259, 1 July 2023, 124542
Resources
Webinar: Explore the power of magnetic beads in modern bioprocessing with our exclusive webinar, “Next-Generation Bioprocessing”
E-book: Bridging the gap between upstream processing and downstream processing by replacing legacy methods of clarification