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MAG-SP
Boosting yield and productivity in monoclonal antibody production with MAGnetic Smart Processing
The challenges of monoclonal antibody manufacturing
The use of monoclonal antibodies (mAbs) as therapeutic modalities has surged over the past few decades. These therapies are now pivotal in medicine, providing more effective treatment options for a wide array of conditions.
While ongoing efforts to improve the manufacturing often focus on upstream bioprocessing enhancements—aimed at generating higher cell mass and boosting volumetric mAb productivity—there is a clear need for innovation in cell clarification and downstream bioprocessing, like affinity chromatography. Specifically, the existing legacy technologies for cell harvesting – cell centrifugation and depth filtration –create bottlenecks that not only creates challenges for capture but impact the overall efficiency of the process.
There is a need for a breakthrough cross-over technology that is able to improve yields and overall productivity by seamlessly integrating upstream and downstream bioprocessing.
Advantages of magnetic separation
Magnetic separation utilizing superparamagnetic magnetic beads emerges as a promising solution, capable of achieving clarification and Protein A capture in a single step, directly from crude cell broth.
This method could replace both centrifugation and depth filtration, integrating the harvest step with Protein A affinity purification.
By doing so, magnetic separation has the potential to significantly enhance yield, throughput, and productivity, while minimizing downstream bottlenecks such as dilution, buffer management, filter clogging, and stoppages.
- 1-step cell clarification and capture directly from crude cell broth
- Replaces centrifugation and depth filtration
- Highly efficient under gentler conditions
- Improved yields, throughput, and productivity
- Reduced downstream bottlenecks to unleash the power of holistic bioprocessing
Introducing MAGnetic Smart Processing, MAG-SP
MAGnetic Smart Processing (MAG-SP) is the world’s first scalable magnetic separation solution, enabling 1-step clarification and capture of biological modalities directly from crude cell broth.
At the core of the MAG-SP platform is our proprietary superparamagnetic MAGic™ Beads technology, built on high-surface agarose resins and customizable for various applications, including monoclonal antibody capture.
Combined with our fully automated, cutting-edge magnetic separator systems (MAGic™ Accio), this platform ensures rapid, gentle, and efficient magnetic separation with a compact footprint.
Thanks to the superior paramagnetic properties and large surface area of the robust resins, the platform sets a new standard in downstream bioprocessing across all scales—from research and pilot stages to full-scale manufacturing.
MAG-SP also offers a green and more sustainable solution for downstream bioprocessing by reducing buffer and water usage, as well as costs associated with energy, labor, materials, wear, and storage.
Skip a step to take a leap in bioprocessing with MAG-SP.
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